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Orthostatic hypotension: May occur especially at the beginning of treatment. The patient should be warned about the possibility of orthostatic hypotension and advised to be careful when rising from a sitting or lying position. At the beginning of treatment, the patient should avoid situations where injury could result from vertigo or nausea. This is particularly important for elderly patients and those concurrently taking other antihypertensives or diuretics.
Accelerated passage through the gastrointestinal tract: If the passage through the gastrointestinal tract is highly accelerated, the absorption and efficacy of the drug may be altered.
Instructions for patients: Patients should be warned to swallow the tablets whole. They should not chew, break or crush them.
Priapism: Prolonged erections and priapism have been reported with alpha-1 blockers including doxazosin in post marketing experience. If priapism is not treated immediately, it could result in penile tissue damage and permanent loss of potency, therefore the patient should seek immediate medical assistance.
Effects on ability to drive and use machines: Especially at the beginning of treatment with Kamiren XL, excessive hypotension may occur and the patient may become dizzy. Driving motor vehicles or operating machinery is not recommended at that time.
Hepatic impairment: In patients with hepatic impairment, the metabolism of doxazosin is slower and caution is required with administration (see also Pharmacology: Pharmacokinetics under Actions).
